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The ISSR includes all the detailed provisions applicable to shipping infectious substances efficiently and safely. Critical shipments that are transported for laboratory tests, being delayed due to non-compliance or other shipping problems could mean a delay to initiating the necessary public health response or identifying the treatment required for a patient.

The ISSR contains documentation and packaging examples, checklists for every step of the process and shipping regulations for air, sea, road, rail, courier and the postal service.

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What’s inside the ISSR?

  • Applicability (legislation, postal authorities, shipper, package supplier and carrier responsibilities, state and vendor variations)
  • Classification (UN numbers, classification criteria and scenarios)
  • Identification (list of dangerous goods, special provisions)
  • Packing (triple packaging, quantity limits, freezing or cooling, certified packing, overpacks, packing instructions)
  • Packaging performance tests (performance tests, finding the right packaging)
  • Marking and labelling (package use marking)
  • Documentation (waybill, how to complete the declaration form, sample documentation by material)
  • Handling (acceptance, checklists, refusals)
  • Emergency response (contact information, responsibilities, spills, leaks, first aid)
  • Training (national requirements, training schools)
  • Dangerous goods security (general provisions, training, high consequence provisions, security plans)

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Stay up-to-date

Significant Changes and Amendments to the 19th edition (2027/2028) of the Infectious Substances Shipping Regulations (ISSR) include:

  • New provision enabling State-related entities to issue guidance on the classification of infectious substances, supporting a faster and more consistent response to emerging public health events, particularly when distinguishing between UN 3373 and UN 2814/2900.
  • Significant updates to State and Operator Variations, including the introduction of new variations from 17 States.
  • Removal of the requirement to include an itemized list of contents for UN 3373 shipments prepared in accordance with Packing Instruction 650.